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Concurrently, GLP-1 enhances SIRT1 expression, which deacetylates the RelA/p65 subunit of NF-B to limit its nuclear translocation, suppressing IL-1 and TNF- at the transcriptional level

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Tirzepatide is a medication classified as a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist