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Of the 49 participants included in the analysis, 40 (82%) were taking ART regimens containing an integrase strand transfer inhibitor, which is a class of antiretroviral drugs shown to be highly effective at suppressing HIV but associated with weight gain in some people

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Another interesting study implied that dapagliflozin mitigated myocardial fibrosis and diabetic cardiomyopathy by suppressing fibroblast activation and endothelial-to-mesenchymal transition via AMPK-mediated inhibition of TGF-/Smad signaling [120]

Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes