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It works through several complementary mechanisms: Appetite suppression: Acts on receptors in the brain (particularly the hypothalamus) to reduce hunger and increase feelings of fullness Delayed gastric emptying: Slows the rate at which food leaves the stomach, prolonging satiety Glucose regulation: Enhances insulin secretion in a glucose-dependent manner and suppresses inappropriate glucagon release Clinical trials have demonstrated that Wegovy, when combined with lifestyle interventions (reduced-calorie diet and increased physical activity), produces significant weight losstypically 1015% of initial body weight over 68 weeks