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The SURMOUNT-5 trial (published in NEJM, 2025) demonstrated mean weight loss of 20.2% with tirzepatide versus 13.7% with semaglutide over 72 weeks in adults with obesity but without diabetes [10]
The tirzepatide syringe injection guide and retatrutide injection guide cover medication-specific technique variations
From these data, the researchers worked out that the relative risk was increased by no more than 31% for those on GLP-1 agonists
Most of Virta's patients aren't on GLP-1s today
