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13 No similar finding has been shown in human studies

It was subsequently found by Ellis Samols and Vincent Marks in 1966 [21] and confirmed by others that glucagon-like immunoreactivity was also present in extra-pancreatic tissues, in particular in the intestine [[22], [23], [24], [25], [26], [27]]

Long-term hyperglycemia promotes renin and angiotensin II synthesis in mesangial cells, leading to elevated glomerular capillary pressure and permeability, which are key components in the development of proteinuria

doi: 10.1007/s11136-004-9567-x
