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Another potential limitation is that the trials had a one-sequence crossover design, and differences in observation/exposure periods make it difficult to compare safety and tolerability profiles between treatment arms

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Monotherapy with the onceweekly GLP1 analogue dulaglutide for 12 weeks in patients with type 2 diabetes: dosedependent effects on glycaemic control in a randomized, doubleblind, placebocontrolled study

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