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Obesity & NAFLD Models Evaluation of chronic tirzepatide exposure on body-weight dynamics, hepatic lipid accumulation, and inflammatory biomarkers in high-fatdiet rodents

Nausea, injection site reactions, and metabolic adaptation occur at similar rates regardless of manufacturing source

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53,54 Therefore, compounds concerning epigenetic targets, such as lysine methyltransferase (KMT), histone lysine demethylase (KDM), histone acetyltransferase (HAT), bromodomain and extra-terminal (BET), histone deacetylase (HDAC) or DNA methyltransferase (DNMT), have entered clinical trials