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Diarrhea, nausea, and vomiting occurred more frequently during dose escalation and declined gradually over time

Zepbound, Lilly Clinical trials like SURMOUNT-1 initiated tirzepatide at 2.5 mg weekly and increased by 2.5 mg every 4 weeks to reach maintenance doses of 5, 10, or 15 mg. The New England Journal of Medicine Maintaining higher doses can sustain or further weight reductionSURMOUNT-4 showed additional ~5.5% loss when continued, versus weight regain with placebo. PMC Important Medical Information and Disclaimers Important Current Status Update : On March 19, 2025, the FDA ended enforcement discretion for compounded tirzepatide

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