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All peptide sequence data, together with experimental potency measurements, were provided and sponsored by AstraZeneca UK Limited

Hepatic fat oxidation: Glucagon signals the liver to break down stored fat (lipolysis) and convert it to energy through oxidation, reducing liver fat content Decreased lipogenesis: Glucagon suppresses the creation of new fat from carbohydrates, particularly in liver tissue Increased energy expenditure: Glucagon activates thermogenic pathways that burn calories as heat rather than storing them as fat Reduced food intake: Glucagon has independent appetite-suppressing effects through actions in the central nervous system Brown fat activation: Animal studies demonstrate glucagon promotes brown adipose tissue activity and thermogenesis The concern about glucagon raising blood sugar is real but manageable

doi: 10.1210/clinem/dgaa130 174 MoulderRHirvonenMKVlikangasTSuomiTOverberghLPeakmanMet al