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Therefore, this study focuses on designing semaglutide analogues with site-specific missense mutations, and aims to strengthen GLP-1R activation through enhanced GLP-1R ECD binding affinity [26], contributing to the development of next-generation GLP-1R agonists with improved efficacy and specificity

But there are some differences from real-world-evidence: Patients were treatment-naive, with diabetes for only about 2.5 years on average

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