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Yes, long-term use is safe according to multi-year clinical trials
Retatrutide and Heart Health Retatrutides effect on the heart is less clear

Effect of EGFR on glucagon like peptide 1 receptor (GLP1-R) As discussed above, there is loss of EGFR mRNA and protein with Cre recombination in the -cell in this model

Common side effects may include nausea, vomiting, diarrhea, abdominal pain, constipation, headache, dizziness, fatigue, or mild injection site reactions