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Preliminary safety reporting indicated: GI adverse event profile consistent with Phase 2 data No new safety signals identified beyond those observed in earlier trials Discontinuation rates due to adverse events were comparable to other GLP-1 class trials Full adverse event tables from TRIUMPH-4 are expected with the peer-reviewed publication

Average results varied by dose and time frame: Participants taking a 4 mg dose lost 47.2 pounds (lb), or about 19 percent of their starting body weight

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Your diabetes team may recommend: Checking blood glucose before bed and upon waking Adjusting doses of other diabetes medications if hypoglycaemia occurs do not adjust insulin or sulphonylurea doses without personalised guidance from your healthcare team Having a small, appropriate bedtime snack if advised by your healthcare team Sleep hygiene practices remain important, as recommended by the NHS and NICE Clinical Knowledge Summaries: [13] Maintain a regular sleep schedule, even at weekends Create a cool, dark, quiet sleeping environment Establish a relaxing bedtime routine Limit screen time for at least one hour before bed Consider relaxation techniques such as deep breathing or progressive muscle relaxation If you have symptoms of obstructive sleep apnoea (snoring, witnessed breathing pauses, excessive daytime sleepiness), discuss this with your GP as you may need referral for assessment