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The term has emerged in informal community discussion as a shorthand for "the third generation of GLP-class peptides" specifically retatrutide, which acts on three receptors (GLP-1, GIP, and glucagon)

Casi todos sus efectos secundarios caractersticos afectan al tracto gastrointestinal: nuseas, vmitos, estreimiento y diarrea

Dai and colleagues studied the uncoupling of GLP-1 responses linked to cell proliferation from those that potentiate glucose-dependent insulin secretion in juvenile versus adult human islets (6)

PubMed Finan, B., Yang, B., Ottaway, N., Smiley, D.L., Ma, T., Clemmensen, C., Chabenne, J., Zhang, L., Habegger, K.M., Fischer, K., Campbell, J.E., Sandoval, D., Seeley, R.J., Bleicher, K., Uhles, S., Riboulet, W., Funk, J., Hertel, C., Belli, S., Sebokova, E., Conde-Knape, K., Konkar, A., Drucker, D.J., Gelfanov, V., Pfluger, P.T., Mller, T.D., Perez-Tilve, D., DiMarchi, R.D., & Tschp, M.H