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All doses of obesity drug retatrutide resulted in clinically meaningful weight loss, while people with severe obesity on the highest dose lost up to 30% of their body weight over two years, topline results of a phase III clinical trial have shown

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Meier, M.A

Specifically, the abundance of some butyrate-producing bacteria (such as the phylum Firmicutes and genus Bifidobacterium ) was reduced, while Gram-negative bacteria were relatively enriched such as the phyla Bacteroidetes and Proteobacteria (30, 31)