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44 The longer aliphatic chain in semaglutide, a long-acting formulation based on the structure of liraglutide, enhances hydrophobicity by altering the DPP-4 enzyme hydrolysis site with polyethylene glycol (PEG), allowing it to strongly bind to albumin

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The root of the tongue connects it to the jaw and to the hyoid bone, while the body stores on its surface four distinct lingual papillae, each with a unique anatomical and functional characteristic and an individual relationship with taste perception (18, 19): The filiform papillae, although the most numerous, have no gustatory functionality, but provide texture sensation and assist in the mechanical manipulation of food

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