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In the AMPLITUDE-O post-hoc analysis, the HR for MACE was 0.70 (95% CI 0.371.30) with baseline SGLT2is and 0.74 (95% CI 0.580.94) without SGLT2is ( P -value for interaction 0.70), and the HR for HHF was 0.23 (95% CI 0.050.97) with SGLT2is and 0.70 (95% CI 0.421.17) without SGLT2is ( P -value for interaction 0.35) [47]

Based on the research available and what I observe in my clinic, I believe the improvements people are experiencing come from overall weight loss and fluid shifts in the body, not because GLP-1s are fixing or healing a damaged lymphatic system

Community and Motivation As with any journey, having the right people around you in a community of support can make all the difference

GLP-1s represent a powerful tool in managing diabetes and obesity, but they also pose significant cost and management challenges for employers and brokers