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Semaglutide and liraglutide have been used for years with reassuring safety profiles

For example, light touch, clothing brushing against the skin, or a gentle breeze can feel intensely painful

The first-line treatment for BED is cognitive behavioral therapy (CBT), which helps to identify and challenge dysfunctional thought and behavior patterns
Consistent with this, GLP-1, exendin-4, and the DPP-4 inhibitor sitagliptin reduced proximal tubular sodium reabsorption in rats [660,761,769,770] and humans [663]