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Description
Since GLP-1R are absent, or are present only at very low levels on hepatocytes, it was also expected that in the absence of ethanol or nutrient regulation GLP-1R agonism would not affect ethanol-metabolizing enzymes
Most patients transition seamlessly within one week, with no tapering or adjustment period needed
Third , the combination lacks robust safety data from controlled trials, meaning potential synergistic effects or unexpected interactions remain inadequately characterized
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