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Normally, when calories are reduced, the body adapts by lowering metabolism

National Library of Medicine : Semaglutide (Wegovy): CADTH Reimbursement Review: Therapeutic area: Weight management [Internet]

Their cravings for food are reduced
Central nervous system GLP-1 receptors are distributed throughout brain regions implicated in depression, including the hippocampus, prefrontal cortex, and nucleus accumbens
