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The original experimental data generated in this study have been deposited in the Mendeley Data repository ( under accession code The MS proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository ( 86 , with the dataset identifier PXD044134

The receptor target is shared, but the experimental design, the model selection, and the interpretive frame all shift when the ligand is a Trp33-dependent, partial, biased small molecule rather than a peptide

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