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Description
At the highest dose, 63% of participants achieved at least 20% body weight reduction versus 1.3% on placebo
Zepbound dosing starts low and gradually increases over a few months
People who are already relatively lean (under 25% body fat for men or under 32% for women) may find that GLP-1 medications produce less dramatic weight loss but still improve body composition through targeted fat reduction
Bottom line: Feeling cold is a frequent, albeit unofficial, experience for those losing weight on GLP-1s, primarily due to the loss of fat insulation and reduced energy intake
