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The SUSTAIN-916 study was excluded from the quantitative analysis because its definition of adverse events potentially leading to lower limb amputation included a broad range of heterogeneous clinical situations, including diabetic neuropathy, hypoesthesia, occlusive peripheral arterial disease, osteonecrosis, paresthesia, and peripheral neuropathy

Finally, patience and realistic expectations are important

Ding L, Yang L, Wang Z, et al
