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This turns down the "volume" on cravings, making alcohol feel less appealing and rewarding
The result is sluggish intestinal movement, which contributes directly to constipation
Activation AKT leads to accumulation of cytosolic -catenin and subsequent translocation to the nucleus where it forms a complex with TCF7L2 (139), a transcription factor that activates expression of Wnt target genes (242)
Amongst people with HF, up to 50% are estimated to have type 2 diabetes and, vice versa, around 20% of the over 500 million people living with type 2 diabetes have been shown to have comorbid HF (Khan et al., 2020)
