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First of all, these are therapeutic decisions in successive steps depending on the success or failure of the previous one

FYI: Retatrutide is also being studied as a type 2 diabetes treatment, where it's shown impressive results for both blood sugar control and weight loss

Guidelines: 2021 ESC Cardiovascular Prevention Question #32 with Dr

47 In patients with overweight or obesity without diabetes, the Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1) trial showed that tirzepatide 15 mg weekly led to a mean body weight reduction of 20.9% after 72 weeks of treatment, compared with 3.1% with placebo