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Combination therapy with SGLT2 inhibitors + GLP-1 RAs may reduce cardiorenal risk and CV & all-cause mortality in T2D vs SGLT22 inhibitor and GLP-1 RA monotherapy

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Whether the positive impact of GLP-1RAs on hepatic histology is indirect, i.e., through their action on extrahepatic tissues, or whether their action is direct, i.e., through activating GLP-1R on the hepatocytes, is still a controversial issue