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Evidence also supports a beneficial effect of exenatide on ectopic fat depots, with potential mechanisms that may not be entirely weight dependent
The SURMOUNT-5 authors hypothesize that GIP receptor expression in subcortical brain regions that regulate food intake doesn't fully overlap with GLP-1 receptor expression, which may explain the additive effect
Additionally, GLP1 has been associated with a reduction in the risk of cardiovascular events in people with obesity, suggesting potential benefits beyond weight loss alone
Safely discard any of these items that have been opened for more than 28 days
