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These are conditions on which randomised control trials have shown GLP-1s to have an effect

Anxiety and inexperience with self-injection, unrealistic expectations, and side-effects can reduce adherence and lead to discontinuation of treatment

Women under atypical antipsychotic treatment showed to have a decreased species diversity in their gut microbiota compared to healthy controls, while men did not show to have this difference [254]

the FDA does not list insomnia as a Wegovy side effect, yet a clinical trial found 7% of patients reported insomnia, and a systematic review of 81 studies did not find a consistent causal link