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Frontiers in immunology, 2017

Similar reductions were observed among adults without diabetes, indicating that both medications were consistently associated with lower rates of several recorded psychiatric diagnoses than this comparator

2025 demonstrates that chronic GCGR agonism downregulates hepatocyte PDE4B/4D phosphodiesterases, producing sustained cAMP-PKA signaling that preserves resting energy expenditure against the adaptive decline of weight loss
