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Description
Effect of pramlintide on satiety and food intake in obese subjects and subjects with type 2 diabetes
11 GLP-1, when bound to GLP-1R, can affect blood glucose levels by stimulating insulin secretion, inhibiting glucagon secretion, suppressing gastric emptying and reducing food intake
The dual agent tirzepatide has pharmacokinetics similar to weekly GLP-1 RAs and exhibits dose-dependent effects on both glucose and appetite regulation
What can be said is that the triple-agonist mechanism appears to produce a steeper dose-response curve than either the dual-agonist (tirzepatide) or single-agonist (semaglutide) approach
