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The starting dose of semaglutide was 0.24 mg once weekly, increased every 4 weeks (to once-weekly doses of 0.5, 1.0, 1.7, and 2.4 mg) until the target dose of 2.4 mg was reached after 16 weeks

Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications primarily used to manage type 2 diabetes and, in some formulations, obesity

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The least-squares mean percentage change in body weight at 24 weeks in the retatrutide groups was 7.2% in the 1 mg group, and up to 17.5% in the 12 mg group, as compared with 1.6% in the placebo group