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Suppress the production of glucose in the liver

In contrast, anti-inflammatory effects on immune cell populations would be reflected by reductions in fecal calprotectin and serum C-reactive protein (CRP) (15, 82)

For type 2 diabetes (NICE NG28), GLP-1 receptor agonists are generally considered after metformin-based therapy has proven insufficient, and can be initiated in primary care according to local formularies and prescribing arrangements

Common reasons to switch include a plateau on Wegovy 2.4 mg, tolerability issues, cost considerations as Wegovy gets more expensive at higher doses, or a change in goals or comorbidities