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472 Promoting the urinary excretion of sodium and water reduces fluid retention and hypervolaemia, thereby reducing the load on the heart
In the two trials, improvements in all prespecified cardiometabolic measures, including waist circumference, systolic and diastolic blood pressure, fasting insulin, lipid, and aspartate aminotransferase levels, were observed with tirzepatide (Jastreboff et al

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