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We proceeded with a sensitivity analysis to calculate an E-value with respect to the relative risk, with a point-estimate E-value of 2.01, suggesting that the observed observation is moderately robust, and that an unmeasured confounder would need to be associated with both GLP-1 and NAION by a risk ratio of at least 2.01 to fully explain away the observed observation

Several factors influence the amount of weight regained after stopping semaglutide

Key Findings 93.4% of patients would get bariatric surgery again 51.4% of patients would consider using GLP-1 drugs again 57.1% of GLP-1 patients reported losing at least 20 pounds 98.1% of bariatric surgery patients reported losing at least 20 pounds Median weight loss for bariatric surgery patients was 100 pounds, as opposed to 20 for GLP-1s Average weight loss for bariatric surgery was reported to be 101.2, as opposed to 24.9 for GLP-1 users 93.4% of Patients Would Get Bariatric Surgery Again Out of all patients surveyed, 93.4% said they would get bariatric surgery again

In the UK, private clinics are beginning to offer lower-dose protocols to clients who arent clinically obese but want tighter control over weight and metabolic health