glp 1 and gip agonist Major physiological roles of GLP-1 GIP. Tirzepatide is acting as an Two incretin hormones GLP-1 and
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Effect of GLP-1 receptor agonists on bone mineral density, bone metabolism markers, and fracture risk in type 2 diabetes: a systematic review and meta-analysis

On the other hand, several shortcomings of the study should be reported to place the context for interpretation of its findings

The clinical evidence behind it is not

GLP-1RAs also reduce food intake by modulating appetite-regulating pathways in the brain, resulting in weight loss (Koide et al., 2025) (see Figure 1)
