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Compounds 47 and 48 (Figure 6), with IC 50 values of 0.83 and 0.43 M, respectively, which possess aryl-substituted piperazines with acetamide linkers, showed the best activity as DPP-4 inhibitors

Liraglutide exerts protective effects by downregulation of PPAR, ACSL1 and SREBP-1c in Huh7 cell culture models of non-alcoholic steatosis and drug-induced steatosis

Study measures Demographics Demographic data, such as age, height and weight (to calculate BMI), gender, race, education and ethnicity were assessed by a demographics questionnaire

Pharmacokinetics and drug metabolism GLP-1RA was developed to be resistant to the degradation of DPP-4