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Regulatory agencies, including the FDA and EMA, have issued warnings about vision loss, stomach problems and risks from unapproved or compounded versions

Tesofensine, during its Phase II trials, led to important decreases in body weight and fat in people who are obese

In retatrutide, the GCGR activity is carefully balanced against GLP-1R and GIPR engagement so that thermogenic benefits are captured without producing net hyperglycaemia