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Random-effects pairwise meta-analyses were performed, and certainty was assessed using GRADE (Grading of Recommendations Assessment, Development, and Evaluation)

Acid reflux with tirzepatide is a common side effect

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Discontinuation rates due to AEs were 12.2% and 18.2% with Retatrutide 9 mg and 12 mg, respectively, compared to 4% with placebo
