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When we think about combining semaglutide and estradiol, the idea is based on how these treatments might work together
Common gastrointestinal side effects occur in the majority of patients and include nausea (reported in 20-50% depending on the agent and dose), vomiting, diarrhea, constipation, and abdominal pain

Duke University in Durham, North Carolina

Some people find taking the injection in the evening (after dinner) is better, so that they sleep through the peak nausea hours
