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When we think about combining semaglutide and estradiol, the idea is based on how these treatments might work together

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Common gastrointestinal side effects occur in the majority of patients and include nausea (reported in 20-50% depending on the agent and dose), vomiting, diarrhea, constipation, and abdominal pain

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Some people find taking the injection in the evening (after dinner) is better, so that they sleep through the peak nausea hours

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