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Several of the PGDPs have important and well-defined (pharmacological) effects on systemic metabolism, including the modulation of food intake and satiety (GLP-1, glucagon, oxyntomodulin), regulation of fluid homeostasis (water intake and urine excretion) (GLP-1) [92], thermogenesis (glucagon), lipid metabolism (GLP-1, glucagon, GLP-2), gastrointestinal motility (glucagon, GLP-1, GLP-2), and gastric emptying (glucagon, GLP-1, GLP-2)