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Y391 GH5 is an essential residue in determining G protein coupling specificity by forming H-bond in class A GPCRs, 30 however, this interaction was not observed among available class B GPCRG protein complexes

From their beginnings as a treatment for type 2 diabetes, GLP-1 receptor agonists such as the semaglutide drugs Ozempic and Wegovy and the tirzepatide drugs Mounjaro and Zepbound have seen an explosion in use, most popularly for weight loss

For long-term success, they should be combined with: Nutrition counseling to support a sustainable dietary pattern Exercise and physical therapy to strengthen the back and core Behavioral coaching to build lasting habits Additionally, patients should avoid the temptation of using GLP-1 medications as a quick fix or without medical supervision