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While joint pain relief is not an FDA-approved indication for GLP-1 medications, emerging clinical observations and patient reports have prompted investigation into potential musculoskeletal benefits

A 2024 study published in JAMA Ophthalmology found that semaglutide users faced a higher risk of developing NAION when treated for diabetes or obesity

That suggests the amylin and GLP-1 pathways create a synergistic interaction, not just a combined one

Additionally, it has been suggested that GIPR agonists and antagonists might target different CNS receptor populations, with evidence showing that acylated peptide GIPR agonists act on GABAergic neurons to further reduce food intake and body weight when combined with GLP-1R agonists in mice 39,40