does glp 1 work for everyone GLP-1 drugs, even when they fail, are giving researchers new insight about obesity : NPR Why Popular Diabetes Drugs Like
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Sitagliptin is considered a competitive enzyme inhibitor, which inhibits the enzyme in a dosedependent fashion, with its dissociation occurring quickly [66]
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In line with this, mice with an -cell specific knock-down of PC1/3, resulting in significantly reduced islet GLP-1 content, were able to maintain normal glucose tolerance, suggesting that islet GLP-1 may not be essential and/or that it can be compensated for by intestinally derived GLP-1 under normal conditions
