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A new Biological Psychiatry review sharpens the case that GLP-1 drugs may affect addiction through brain reward circuits, not simply by reducing appetite
It reduces all-cause and cardiovascular deaths
GLP-1 directly activates POMC/CART neurons and indirectly inhibits, via GABAergic transmission, the neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons, which collectively results in signals that reduce food intake
