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While studies and assessments of GLP-1 AOMs, such as the cost-effectiveness study by the Institute for Clinical and Economic Review (ICER), 24 emphasize the potential for improved outcomes in obesity-related chronic diseases (e.g., heart disease, diabetes, osteoarthritis) and the potential related savings, the cost of AOMs must be paid up front, often exceeding the political or financial capacity of state legislatures to fund the program adequately

Semaglutide commonly causes mild nausea, constipation, or fatigue, while ashwagandha is generally well-tolerated but may cause drowsiness or mild GI upset

The eGFR increase in the obesity trial was accompanied by a significant UACR decrease in the retatrutide group, suggesting that the increase in glomerular filtration was accompanied by a lower intraglomerular pressure and kidney stress

Ozempic is approved for people 18 years of age and over