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10.1016/j.cell.2007.05.047 38 LiangW.KhatriI.SchellekensH.GarssenJ.WesterhoutJ

This nucleus is the first stop for all the signals coming from the gastrointestinal tract via the vagus nerve, and its directly connected to many other brain areas controlling feeding

But we were also curious about how GLP-1 and GIP impacted insulin and glucagon secretion. Researchers were surprised to find there were no differences with glycemic control even though the kidney disease patients were secreting more GLP-1 and GIP

For subcutaneous semaglutide, we recommend starting 0.5 mg once weekly for 4 weeks before advancing to 1 mg once weekly, depending on tolerability and clinical necessity