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A provider has pointed out, The biggest challenge is deciding whether to prescribe medication for patients with BMI near the 30% cutoff, as small variations in weight can significantly impact eligibility. Ethical dilemmas arise when patient expectations are set too high, balancing clinical appropriateness with patient expectations when data foundations are not trustworthy

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The mean reduction in A1c with SGLT2-I ranged from 0.32% to 1.17%

Abbreviations CNRC: Childrens Nutrition Research Center FFM: Fat-free mass GIP: Gastric inhibitory polypeptide GLP-1: Glucagon-like peptide-1 GPR: Glucose production rate HISI: Hepatic insulin sensitivity index IGI: Insulinogenic index iGLP-1: Intact GLP-1 MIGHTY: Metformin Influences Gut Hormones in Youth NGT: Normal glucose tolerance NIH: National Institutes of Health PYY: Peptide YY R a : Rate of appearance WBISI: Whole-body insulin sensitivity index References Zeitler P, Hirst K, Pyle L et al (2012) A clinical trial to maintain glycemic control in youth with type 2 diabetes