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Variations in baseline hormone levels, insulin sensitivity, and metabolic rate all contribute to individual response differences

January 2026: Amgen completed Phase 3 enrollment for MariTide (AMG 133) in the MARITIME-Obesity trial, with interim efficacy data expected in Q3 2026 that will position the monthly injection GLP-1/GIP antagonist as a once-monthly obesity treatment alternative

Improved Insulin Sensitivity : Aids individuals with insulin resistance by enhancing the bodys ability to use insulin effectively

Length of the break (short vs over 4 weeks may require dose adjustment) Reason for stopping (surgery, side effects, or other factors) Digestive recovery and ability to eat normally Reduced tolerance after a break (risk of nausea or dose shock) Type of surgery and overall recovery status Other medications or health changes during recovery Signs Youre Ready to Restart Mounjaro Restarting Mounjaro should be based on recovery, not timing alone