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Most people with type 1 diabetes need a very small dose, says Szoke

Furthermore, the expanding investigation of semaglutide in Alzheimer's disease through the EVOKE Plus trial program, anticipated to report results by 2026 and 2027, represents a potentially enormous new indication that could add tens of millions of patients to the addressable treatment population globally, with corresponding API volume requirements that dwarf those of the existing obesity and diabetes indications

These medications, categorized as GLP-1 agonists, were originally approved for the treatment of Type 2 diabetes but have since become popular for their weight-loss benefits

Recent reports have connected Ozempic to fatal adverse events, with notable cases including sudden deaths linked to gastroparesis (or stomach paralysis), bowel obstruction, and, in rare cases, life-threatening conditions such as pancreatitis and gallbladder disease