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Interpreting results through the lens of any single receptor pathway will produce incomplete mechanistic conclusions

In all SURPASS programs, tirzepatide demonstrated a much greater HbA1c-lowering impact than placebo or active comparators, such as basal insulin and GLP1RAs [83, 86]

[DOI] [PubMed] [Google Scholar] 157.Day J.W., Gelfanov V., Smiley D., Carrington P.E., Eiermann G., Chicchi G., Erion M.D., Gidda J., Thornberry N.A., Tschp M.H., et al

Amy Schroeder Principal Research Scientist | July 9, 2025 Current Landscape Overview Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) are an emerging drug class that are mostly indicated to improve glycemic control in patients with type 2 diabetes mellitus (T2D) and reduce body weight