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The presence of the rs6006460 T allele appears to have a protective effect against the accumulation of TG in hepatocytes, which could reduce the risk of developing MASLD [262]
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Other pharmacological options include older weight loss medications such as phentermine-topiramate and naltrexone-bupropion, which have different mechanisms of action and may be appropriate for some patients
Tirzepatide cardiovascular outcome trials are ongoing
